ω-Tbo-IT1 – Ion Channels and Transporters

ω-Tbo-IT1 has been isolated from the venom of the Tibellus oblongus spider. ω-Tbo-IT1 is a selective blocker of insects calcium channels. It has been shown that ω-Tbo-IT1 has a potent insect toxicity with LD50 19 μg/g on house fly Musca domestica larvae and LD50 20 μg/g on juvenile Gromphadorhina portentosa cockroaches. Electrophysiological experiments revealed a reversible inhibition of evoked excitatory postsynaptic currents in blow fly Calliphora vicina neuromuscular junctions with an IC50 value 40 ± 10 nM.

Technical specification

	Sequence :	H-CASKNERCGNALYGTKGPGCCNGKCICRTVPRKGVNSCRCM-OH (Cys1-Cys21; Cys8-Cys25; Cys20-Cys40)
	MW :	4331.74 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
ITO001-0.1 mg	0.1 mg	330 €	264 $
ITO001-0.5 mg	0.5 mg	1 155 €	924 $
ITO001-
ITO001-
ITO001-

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