TAT – GluR23Y – TAT Conjugated Peptides

TAT-GluR23Y is a cell penetrating peptide that inhibits phosphorylation of AMPA receptor endocytosis. Recent studies have shown that AMPA receptor endocytosis, which is a cellular mechanism underlying the formation of LTD, plays a critical role in facilitating initial extinction of learned fear. Tat-Glur23Y can block regulated AMPA and thereby prevents long-term depression (LTD) in structures such as the nucleus accumbens and dorsal hippocampus.