TAT-AKAP79 (326-336) amide – TAT Conjugated Peptides

The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma, and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons, and the neurotransmitter anandamide.- The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia. This product is composed of the TRPV1 interacting residues of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain at the N-terminus. This product was shown in vivo to have a potent analgesic affect due to interaction with TRPV1 but not affect the pain threshold. This product is a vital tool for research into suitable TRPV1 antagonists.