TAMRA-ShK – Ion Channels and Transporters

TMR-ShK is a fluorescent (red) derivative of the well-known ShK toxin (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) with a Kd value of 11 pM, 16 pM, 312 pM and 165 pM, respectively. The fluorescent TMR-labeled ShK blocks Kv1.3 and Kv1.1 with Kd values of 52 pM and 397 pM, respectively. TMR-ShK can be used to identify lymphocytes expressing Kv1.3 channels such as effective memory T cells (TEM) in the case of autoimmune diseases (type 1 diabetes, mellitus or rheumatoid arthritis) which overexpress Kv1.3 channels.

Technical specification

	Sequence :	H-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC-OH (Cys3-Cys35; Cys12-Cys28; Cys17-Cys32)
	MW :	4054.78 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
SAT001-0.1 mg	0.1 mg	330 €	264 $
SAT001-0.5 mg	0.5 mg	1 155 €	924 $
SAT001-1 mg	1 mg	1 964 €	1571 $
SAT001-
SAT001-

If you’d like to learn more about this toxin, visit our product page on our Smartox website—Our sister company specializing in the synthesis of complex toxins.

TAMRA-ShK – Ion Channels and Transporters

Technical specification

Price

For Bulk Orders