SMAC/DIABLO-[Cys(AF647)] – Fluorescent Peptides

SMAC/DIABLO-[Cys(AF647)] is a pro-apoptotic peptide that is derived from the mitochondrial protein known either as Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (DIABLO). During apoptosis the mitochondria has increased permeability to Smac/DIABLO, which causes the protein to diffuse into the cytosol. Here, Smac/DIABLO adheres to Inhibitors of apoptosis proteins (IAPs) and prevents them from binding to caspases, which in turn accentuates apoptosis.
This peptide has a C-terminal cysteine linker labelled with AF647, which is a bright, far-red-fluorescent dye with excitation between 594 nm and 633 nm.

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