Pseudin-2 – Antimicrobial Peptides – AMP

Pseudin-2 (Ps) is one of the four pseudin peptides isolated from the skin of the paradoxical frog Pseudis-paradoxa. Pseudins are structurally related, cationic, amphipathic, a-helical anti-microbial peptides (AMP) that share sequence homology with an apoptosis regulating protein. Pseudin-2 is the most abundant and potent of the four pseudins. Pseudin-2 is active against Escherichia coli (with minimum inhibitory concentrations (MIC) of 2.5 mM), Staphylococcus aureus (MIC: 80 mM), and Candida albicans (MIC: 130 mM). Pseudin-2 also has low haemolytic activity against human erythrocytes (the concentration of Pseudin-2 producing 50% haemolysis: >300 mM). In addition to its anti-microbial properties, pseudin-2 has also been shown to stimulate insulin release and may be useful as a therapy for type 2 diabetes. This peptides has a non-amidated C-terminal end, as per the naturally occurring pseudin-2.