Proapoptotic Peptide KLA – Cancer Peptides

Proapoptotic peptide KLA is a cationic amphipathic peptide that disrupts the mitochondrial membrane. Proapoptotic peptide KLA cannot of its own accord cross eukaryotic cell membranes and is therefore not toxic to the latter. However, KLA has been fused to various protein transduction domains (PTDs) to study its effects in cells. With the fusion of PTDs such as penetratin, KLA becomes highly toxic to cancer cells, it disrupts the mitochondrial cell membrane releasing cytochrome C. This induces cytotoxicity and triggers apoptosis while not effecting normal cells. This selectivity makes KLA-fusion peptides an ideal candidate for further research into cancer treatments as it provides targeted delivery of a highly toxic peptide that only seems to effect cancerous cells. Proapoptotic peptide KLA is provided here to research grade quality, potential PTDs are also available in our catalogue.