Peripheral Myelin Protein P0 (180-199) – Other Categories

Myelin protein zero (MPZ- also termed P0), together with myelin basic protein (MBP- previously termed P1), mediates adhesion between adjacent extracellular membrane surfaces in order to compact the myelin membranes. Myelin protein zero (P0) is the most abundant myelin protein in the peripheral nervous system (PNS), where it is believed to be adhesive on both sides of the membrane through its extracellular and intracellular domains. The extracellular domain of P0 comprises a single Ig domain, whereas the cytoplasmic end is highly positively charged and not predicted to fold into a globular domain.