PA protein (Influenza A virus) – Antimicrobial Peptides – AMP

The PA protein is a subunit of the influenza virus polymerase complex and its endonuclease activity is vital in viral genome replication. As a phosphoprotein it is a casein kinase substrate and its N-terminus is responsible for the activation of a proteolytic process in which co-expressed proteins are degraded. During viral RNA synthesis PA produces 5′ capped RNA oligonucleotides due to it cleaving the 5′ terminus on pre-mRNA. It is possible that the PA protein could be used as a target in antiviral chemotherapy.