P7 – GPCR Modulators

G protein-coupled receptor 56 (GPR56/ ADGRG1) is a novel and evolutionarily conserved regulator of peripheral nerve development and function, with important implications for human health and disease. During Schwann cell (SC) development, GPR56-dependent RhoA signalling promotes timely radial sorting of axons. In the mature peripheral nervous system (PNS), GPR56 is localised to distinct SC cytoplasmic domains. Here it is required to establish proper myelin thickness, and facilitate organisation of the myelin sheath.