Nictide – Other Categories

LRRK2 is a leucine rich repeat kinase 2. Increase in LRRK2 kinase activity due to mutation has been linked to numerous forms of Parkinson disease (PD). Theoretically, identification of suitable inhibitors of LRRK2 could be the basis for treatments of PD. Markers of LRRK2 activity and function are available that may be clinically relevant in the future as prognostic indicators. Nictide is a substrate model peptide for LRRK2 activity in in vitro kinase assay analysis. -LRRK2 phosphorylates Rab GTPases and alters their association with effector proteins leading to changes in a vast array of cellular functions including the immune response. The use of in vitro kinase assays with small molecules substrates makes screening for LRRK2 inhibitors possible. Alongside nictide, LRRKtide is also used in the same in vitro assays as a substrate model peptide for LRRK2.- Nictide and LRRKtide are available in our catalogue.