Myelin Basic Protein (MBP) (68-82), guinea pig – Myelin Basic Protein (MBP) Peptides

The 14 amino acid fragment of myelin basic protein (MBP) (68-82) can induce experimental allergic encephalomyelitis (EAE) in Lewis rats. EAE is the most used experimental model for studying the human inflammatory demyelinating diseases, such as multiple sclerosis (MS). MBP is an integral component of myelin found in the central nervous system (CNS). MBP is considered vital for the development and stability of the myelin sheath where it plays a role in membrane adhesion. MPBs constitute an extraordinarily varied collection of splice isoforms which show a myriad of post-translational modifications. MBP may be targeted by auto-antibodies in diseases such as MS. Use of MBP fragments in immunology assays are helping to answer this. The low affinity of MBP (1-9) peptide for major histocompatibility complex (MHC) class II molecules may result in MBP autoreactive T cells escaping central-tolerance, where self-reactive T cells are usually eliminated. The activity induced by MBP (68-82) suggests it can cause EAE but other EAE MBP peptides were found to induce a stronger response. The MBP (68-82) and others available in our catalogue may help to understand the nature of demyelinating diseases and find the target autoantigens of conditions such as MS.