Leptin (116-130) Mouse – Neuroscience Peptides

Leptin is a member of the adipocytokines or adipokines group of cytokines which are primarily produced in adipose tissue. Leptin is both a hormone involved in multiple endocrine functions, bone metabolism and thermoregulation, and a cytokine that promotes inflammatory responses. People with obesity have elevated levels of leptin. This contributes to the state of low-grade inflammation that makes those individuals more likely to develop cardiovascular diseases, type II diabetes, degenerative disease and autoimmune disease. Reduced levels of leptin, found in malnourished individuals, has been linked to an increased risk of infection and reduced cell-mediated immunity. Leptin binds to leptin receptors (ObRs), of which there are at least six isoforms (ObRa, ObRb, ObRc, ObRd, ObRe, and ObRf). This fragment of leptin has been shown to restrict weight gain and food intake in female mice lacking active leptin.