IL-33 peptide – Immunology – Antigens/Epitotes/Pools/Librairies

IL-33 is a member of the IL-1 superfamily of cytokines, a determination based in part on the molecules β-trefoil structure, a conserved structure type described in other IL-1 cytokines. IL-33 acts intracellularly as a nuclear factor and extracellularly as a cytokine. IL-33 has been associated with several disease states through Genome Wide Association Studies: asthma, allergy, endometriosis and hay fever. A single-nucleotide polymorphism rs928413 (A/G), is located in the 5′ upstream region of IL33 gene, and its minor ‘G’ allele was identified as a susceptible variant for early childhood asthma and atopic asthma development.