Human Lysozyme (107-115) – Antimicrobial Peptides – AMP

Human Lysozyme (107-115) is derived from human lysozyme, a glycosidase enzyme which can kill both gram-positive and gram-negative bacteria. This can be carried out in a catalytic manner through the hydrolysis of peptidoglycan in the cell wall or alternatively in a non-catalytic manner. Due to the surface of bacteria being negatively charged, they are vulnerable to be targeted by the human lysozyme which is cationic. These antimicrobial properties can be used therapeutically as an anti-pseudomonal agent. Structurally the human lysozyme is comprised of four intramolecular disulphide bonds, four alpha helices within an alpha domain and β-sheets within a β-domain. Human lysozyme (107-115) is found within the α-domain.