Guangxitoxin-1E – Ion Channels and Transporters

Guangxitoxin-1E (GxTx-1E) was isolated from the venom of Chilobrachys jingzhao (Chinese earth tiger tarantula). Guangxitoxin-1E was shown to block Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3 channels without significant effect on Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.5/KCNA5, Kv3.2/KCNC2, Cav1.2/CACNA1C, Cav2.2/CACNA1B, Nav1.5/SCN5A, Nav1.7/SCN9A or Nav1.8/SCN10A channels. Guangxitoxin-1E inhibits Kv2.1 with an IC50 value of 1 nM and Kv2.2 with an IC50 value of 3 nM. Block of Kv4.3 occurs at 10-20 fold higher concentrations. Guangxitoxin-1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials. In pancreatic beta-cells, Guangxitoxin-1E enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations.

Technical specification

	Sequence :	H-EGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP-OH (Cys4-Cys19; Cys11-Cys24; Cys18-Cys31)
	MW :	3948.70 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
11GUA002-0.05 mg	0.05 mg	110 €	88 $
11GUA002-0.1 mg	0.1 mg	187 €	150 $
11GUA002-0.5 mg	0.5 mg	655 €	524 $
11GUA002-5 x 0.01 mg	5 x 0.01 mg	165 €	132 $
11GUA002-

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Guangxitoxin-1E – Ion Channels and Transporters

Technical specification

Price

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