GsAF-2 – Ion Channels and Transporters

GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.

Technical specification

	Sequence :	H-YCQKWMWTCDEERKCCEGLVCRLWCKKKIEW-OH (Cys2-Cys16; Cys9-Cys21; ; Cys15-Cys25)
	MW :	3201.54 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
12GSF002-0.1 mg	0.1 mg	220 €	176 $
12GSF002-0.5 mg	0.5 mg	660 €	528 $
12GSF002-1 mg	1 mg	1 045 €	836 $
12GSF002-
12GSF002-

If you’d like to learn more about this toxin, visit our product page on our Smartox website—Our sister company specializing in the synthesis of complex toxins.

Visit Smartox product page

Get a Quote

For Bulk Orders

Get a Quote