gp91 ds-TAT – TAT Conjugated Peptides

The gp91 ds-TAT peptide is composed of a gp91phox sequence conjugated to the human immunodeficiency virus-TAT peptide. The TAT sequence facilitates its entry into all cells, hence it is a cell-penetrating peptide. The gp91 peptide is the haem binding sub-unit of the superoxide-generating NADPH oxidase. As a result, the gp91 ds-TAT peptide can be used as a selective inhibitor of NADPH oxidase assembly. Recent studies have shown that gp91 ds-TAT can increase blood nitric oxide bioavailability in hind limb ischaemia and reperfusion by inhibiting NADPH oxidase.