FEFEFKFK – Other Categories

The ionic-complementary octapeptide, FEFEFKFK, can self-assemble into antiparallel β-sheet rich fibres and forms very stable hydrogels when at a concentration of more than 20 mg/mL (in water). These peptide hydrogels are naturally biocompatible and biodegradable and can be metabolised by the body. Such hydrogels have been shown to mimic the structure of the extracellular matrix, thus offering cells a niche to undertake their physiological functions. These properties mean that these hydrogels have the potential for use in medical applications. FEFEFKFK hydrogels are able to support the culture of cells such as mesenchymal stem cells in three dimensions with sustained cell viability. They can also support the differentiation into osteoblasts and promote mineralisation upon addition of osteogenic stimulation. They therefore have potential for use in the regeneration of hard tissues such as alveolar bone following injury or degeneration.