BMF – Other Categories

Bcl-2-modifying factor (Bmf) belongs to the BH3-only class of Bcl-2 family proteins (along with Bim). Bmf has pro-apoptotic activity and can trigger mitochondrial apoptosis via inhibition of CAP-dependent protein synthesis, it is also involved in B cell development and anoikis. Bmf activity is regulated by dynein light chain (DYNLL) 1 and 2, via inducing its homo-dimerization and leading to the formation of ternary complexes (such as Bim-DYNLL-Bmf).