Biotin phosphorylated CDK7 (157-169) – Biotin Labeled

Cyclin-dependent kinases (CDKs) are a family of kinases that regulate the cell cycle and gene transcription. Cyclin-dependent kinase 7 (CDK7) forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK) and promotes cell cycle progression. CDK7 is an essential component of the transcription factor TFIIH, involved in DNA repair. CDK7 is also implicated in mRNA processing, transcription activation, pause induction, and pause release. Cyclin-dependent kinases play key roles in cancer development and metastasis. CDK7 is over expressed in many types of cancer such as breast cancer and renal cell carcinoma (RCC). High CDK7 expression is often seen in more advanced stage tumours, is associated with poor prognosis and is correlated with poor response to endocrine treatment. This peptide contains an N-terminal biotin tag for simple detection and purification.