BAM (8-22) – Immunology – Antigens/Epitotes/Pools/Librairies

BAM (8-22), the Bovine adrenal medulla 8-22 peptide is synthesised from proekephalin after it has undergone proteolytic cleavage. It can induce what is known as the ‘itching’ or ‘scratching’ response through activating, using an opioid independent mechanism, the G-protein coupled receptor MRGPRX1. This subsequently activates the Gαq/11 pathway and the cation channel TRPA1 histamine independent itch pathways. It is believed that BAM 8-22 can contribute to chronic itching in diseases such as cholestasis-related pruritus, in which patients are commonly diagnosed as having a reduction in bile flow.