ATTO488-ProTx-I – Ion Channels and Transporters

ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a) is a fluorescently labeled ProTx-I that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2. ProTx-I is also an antagonist of TRAP1.

Technical specification

	Sequence :	ATTO488-ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS-OH (Cys2-Cys16; Cys9-Cys21; Cys15-Cys25)
	MW :	3987.50 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
PTF003-0.01 mg	0.01 mg	138 €	110 $
PTF003-0.1 mg	0.1 mg	660 €	528 $
PTF003-0.5 mg	0.5 mg	1 980 €	1584 $
PTF003-5 x 0.01 mg	5 x 0.01 mg	550 €	440 $
PTF003-

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ATTO488-ProTx-I – Ion Channels and Transporters

Technical specification

Price

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