[5-FAM]-SRC Substrate Peptide – Fluorescent Peptides

Substrate peptide for Scr, tyrosine kinase, for use in in vitro assays for Src activity. Src is a member of the Src Family tyrosine Kinases (SFKs), a large cytosolic, non-receptor, kinase family that controls multiple signalling pathways in animal cells. Src is a tyrosine kinase proto-oncogene and elevated levels of Src protein are seen in different tumours including: breast- lung- thyroid- glioblastoma- colorectal- pancreatic- prostate- gastric- biliary tract and skin cancer. Src levels are often associated with tumour progression, metastasis, and a poor clinical outcome and therefore Src has been investigated as a therapeutic target. Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.