α-conotoxin-IMI – Ion Channels and Transporters

α-conotoxin IMI (alpha-conotoxin IMI) is a conopeptide that has been isolated from the venom of the cone snail Conus imperialis. α-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). α-conotoxin IMI is a selective blocker of α7 homomeric nicotinic acetylcholine receptors (IC50 ~ 200 nM). It has no effect on nAChRs composed of α2/ß2, α3/ß2, α4/ß2, α2/ß4, α3/ß4, or α4/ß4 subunits. α-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.

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