Custom Peptide Synthesis

Peptide synthesis expertise

SB-PEPTIDE is specialized in chemical polypeptide synthesis. Solid-Phase Peptide Synthesis (SPPS) consists in conjugating several amino acids (c.f. amino acids chart) to obtain a peptide chain. SB-PEPTIDE offers to synthesize simple to complex peptides (highly hydrophobic sequences, highly hydrophilic, long sequences, cyclized peptides, fluorescent peptides, KLH-BSA conjugated peptides, or other modifications), for occasional or recurrent projects. SB-PEPTIDE can synthesize individual peptides (purified or not), peptide pools, proteins and peptide libraries (96 wells plate).

Custom synthesis of individual peptides

SB-PEPTIDE offers several standard synthesis scales (from mg to multi-grams) and purity rates for custom peptide synthesis.

peptide synthesis

Standard synthesis scales and purity rates

Any other scales (intermediates or multi-grams) are possible, as well as specific purity rates. Feel free to ask the best format for you when submitting your quote request.

Thanks to the use of chemical routes for peptide synthesis, unlimited modifications are possible on individual peptides, including on small proteins. Discover some of the available peptide modifications here.

Polypeptide synthesis options

SB-PEPTIDE can upgrade customized peptides with various options including TFA removal, NPC determination by AAA, Endotoxin-free service… Discover all options here

Custom peptide synthesis in 10 days

Custom peptide synthesis is a multi-step prossess, starting from the chemical synthesis of a crude peptide, its purification, eventual modifications, preparation for delivery with quality controls all along the process. SB-PEPTIDE usually delivers standard peptides in 4 weeks.

In case of urgent needs, SB-PEPTIDE has been the first peptide company (to its knowledge!) to offer a 10 days express production service. The peptide express service is also available for modified and purified peptides. Visit peptide synthesis express service here.

10 days express service

Discover now

Quote and lead time estimation

Custom Peptide Synthesis prices

SB-PEPTIDE offers premium custom peptide synthesis services at competitive prices. We invite clients to submit a quote request for every project. The feasibility of each peptide will be analyzed and an adapted quote will be sent, usually in less than 4 hours.

Enjoy exclusive benefits

More information about SB-PEPTIDE exclusive benefits here.

A wide range of options

Discover all available options here

References

Peptide synthesis - Wikipedia presentation

General principle of peptide synthesis : https://en.wikipedia.org/wiki/Peptide_synthesis

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

Merrifield RB (1963). Journal of the American Chemical Society: https://pubs.acs.org/doi/10.1021/ja00897a025

Synthesis of proteins by native chemical ligation.

A simple technique has been devised that allows the direct synthesis of native backbone proteins of moderate size. Chemoselective reaction of two unprotected peptide segments gives an initial thioester-linked species. Spontaneous rearrangement of this transient intermediate yields a full-length product with a native peptide bond at the ligation site. The utility of native chemical ligation was demonstrated by the one-step preparation of a cytokine containing multiple disulfides. The polypeptide ligation product was folded and oxidized to form the native disulfide-containing protein molecule. Native chemical ligation is an important step toward the general application of chemistry to proteins.

Dawson PE, Muir TW, Clark-Lewis I, Kent SB (1994). PMID: 7973629